Action Required, to Preserve and Protect

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Taking action on developmental toxicity: Scientists’ duties to protect children

BACKGROUND Although adaptation and proper biological functioning require developmental programming, pollutant interference can cause developmental toxicity or DT. OBJECTIVES This commentary assesses whether it is ethical for citizens/physicians/scientists to allow avoidable DT. METHODS Using conceptual, economic, ethical, and logical analysis, the commentary assesses what major ethical theo...

Deadly Wells: Taking Action to Protect Future Generations

Children around the world are now confronting serious health risks from environmental hazards that were neither known nor suspected before. Over 40% of the global burden of disease attributed to environmental factors falls on children aged less than five years. Thousands of chemical compounds have been developed over the last 50 years. Considering economic and social development, proper actions...

The Digital Signature Dilemma: To Preserve or Not to Preserve

Since the mid-1990s, dozens of States, including those of the EU, have reformed their evidence laws so as to grant digital signature technologies the same proof value as handwritten signatures, as a mechanism for proving identity of authorship, consentement to obligations, and integrity of electronic records after their transmission across time and space. Yet, several archival institutions (inc...

Tsc1 expression by dendritic cells is required to preserve T-cell homeostasis and response

Dendritic cells (DCs) are pivotal to the induction of adaptive T-cell immune responses. Recent evidence highlights a critical role of tuberous sclerosis complex 1 (Tsc1), a primarily upstream negative regulator of mammalian target of rapamycin (mTOR), in DC development, but whether and how Tsc1 directly regulate mature DC function in vivo remains elusive. Here we show that selective disruption ...